The 2008 Ford E-350 uses a four-speed automatic transmission, typically the Ford 4R100, paired with the 5.4L V8 or the 6.8L V10 gasoline engines.
Overview of the E-350 drivetrain in 2008
In 2008, the E-350 Super Duty van was part of Ford's E-Series lineup. Most configurations employed a four-speed automatic transmission to drive the rear wheels, with no factory manual option for this model year. The transmission was designed to handle the van’s torque and payload, paired with Ford’s large V8 or V10 gasoline engines.
Engines that pair with the transmission
The standard engine was the 5.4L Triton V8, with the 6.8L Triton V10 available as an option. Both engines were typically mated to the same four‑speed automatic transmission, providing the necessary torque for hauling cargo or passengers.
How to verify your exact transmission in a given vehicle
Because fleets and upfits can vary, it’s best to confirm the exact transmission on a specific vehicle by checking the VIN for the factory equipment code, inspecting the transmission pan code, or consulting a Ford dealer with the VIN for the precise specification.
Summary
In summary, the 2008 Ford E-350 generally uses a four-speed automatic transmission (the Ford 4R100) behind the 5.4L V8 or the 6.8L V10 engines. For certainty on a particular vehicle, verify with the VIN or the transmission stamping.