The 2016 Honda Odyssey with its 19.5-gallon fuel tank and a 3.5-liter V6 engine typically covers about 430 miles on mixed driving, with highway trips potentially exceeding 540 miles per tank.
To understand why, it helps to look at the tank size, the EPA fuel economy ratings, and how those figures translate into range under different conditions. All 2016 Odysseys are front-wheel drive, and the efficiency figures come from EPA testing used to estimate real-world mileage.
Fuel capacity and efficiency
The 2016 Honda Odyssey lists a fuel tank capacity of 19.5 gallons. The EPA ratings for the front-wheel-drive model are 19 mpg in the city, 28 mpg on the highway, and 22 mpg combined. Those numbers form the baseline for estimating range per tank. Keep in mind that real-world mileage varies with driving style, terrain, cargo, climate, and maintenance.
What that means for range
Estimate range by multiplying the tank capacity by miles per gallon for the applicable driving condition. Using the 19.5-gallon tank and the EPA figures, rough estimates are:
- Highway driving (about 28 mpg): roughly 546 miles per tank.
- Mixed driving (about 22 mpg): roughly 429 miles per tank.
- City driving (about 19 mpg): roughly 370 miles per tank.
These figures illustrate how driving style and conditions can swing the total miles per tank by several hundred miles. Real-world results will vary from the estimates above.
Summary
The 2016 Honda Odyssey offers a practical per-tank range driven by a 19.5-gallon tank and EPA-favored efficiency around 22 mpg combined. Expect about 370 miles in city conditions, around 430 miles with mixed driving, and more than 540 miles on sustained highway cruising. Always factor in load, terrain, and climate, which can noticeably affect actual mileage.


