A 2006 Honda Odyssey generally gets about 17 mpg in the city and 25 mpg on the highway (roughly 20 mpg combined). This article explains the official EPA ratings, real-world variation, and factors that influence mileage.
Official fuel-economy estimates for the 2006 Odyssey
The 2006 Odyssey uses a 3.5-liter V6 with a 5-speed automatic transmission. The figures below reflect the standard 2WD configuration and provide a baseline for what drivers typically experience in mixed driving conditions.
Before listing the numbers, note that the values below are the EPA city/highway estimates commonly cited for that model year.
- City: 17 miles per gallon
- Highway: 25 miles per gallon
- Combined: about 20 miles per gallon
These figures serve as a guide. Real-world mileage can vary based on several practical factors discussed later in the article.
What influences fuel economy on the 2006 Odyssey
Several factors shape the mileage you actually see day to day. The following list highlights the main influences.
- Vehicle weight and trim level: LX, EX, EX-L, and Touring trims carry different equipment and wheel setups that can affect efficiency.
- Tire size and condition: Tire width and rolling resistance can alter fuel economy.
- Driving style: Aggressive acceleration and high speeds reduce mpg; steady cruising typically improves it.
- Maintenance and age: Regular maintenance, a clean air filter, and proper alignment help sustain efficiency on an older vehicle.
- Load and roof accessories: Extra passengers, cargo, and roof racks increase aerodynamic drag and reduce mpg.
In practice, a well-maintained 2006 Odyssey tends to land around the 20 mpg combined mark, with highway driving usually in the mid-20s and city driving closer to the high teens depending on conditions.
Trims and mpg differences
Although the engine and transmission are consistent across trims, wheel choices and overall weight can yield small variations in mileage. The common expectation is that LX, EX, EX-L, and Touring models fall near the same EPA values, with real-world results varying by tires and driving conditions.
LX and EX models
Typical estimates align with the standard EPA numbers: about 17 mpg city and 25 mpg highway, with roughly 20 mpg combined in mixed driving.
EX-L and Touring models
Top-tier trims may carry more equipment and heavier wheels, potentially nudging real-world mpg slightly lower in some situations, but overall figures stay close to the baseline estimates.
Tips to maximize mpg on a 2006 Odyssey
Maximizing fuel efficiency involves a combination of maintenance and driving habits. Consider these practices to improve mileage.
- Keep tires properly inflated to the recommended pressure and rotate them as advised.
- Schedule regular maintenance (air filter, spark plugs, fluids) to maintain engine efficiency.
- Avoid excessive idling and heavy acceleration; use smooth, steady acceleration and consistent speeds when possible.
- Remove unnecessary weight from the vehicle and minimize aerodynamic drag (roof racks when not in use).
With good maintenance and mindful driving, you can approach or slightly exceed the typical combined mpg range for the model year.
Summary
The 2006 Honda Odyssey typically achieves around 17 mpg in the city and 25 mpg on the highway, about 20 mpg combined, with variations based on trim, tires, and driving behavior. Understanding EPA estimates and factoring in real-world conditions can help set realistic expectations for this older minivan.
How much is a 2006 Honda Odyssey worth today?
Estimated Values
Estimated Trade-In Values for the 2006 Honda Odyssey EX-L Minivan 4D range from about $1,300 to $1,825 depending on vehicle condition. Estimated Private Party Values range from about $2,750 to $3,625 depending on vehicle condition. Valid for ZIP Code 29401 through 4/23/2026.
What year to stay away from Honda Odyssey?
The 2002 model happens to be one of the worst Honda Odyssey models, with the most reported incidents in the model's history. The primary issue (again) was the transmission, which started giving drivers problems around 109,000 miles.
How big is a 2006 Honda Odyssey gas tank?
21.0 gal
Fuel & MPG
357.0/546.0 mi. 21.0 gal.
What is the best tire for a Honda Odyssey?
Best Honda Odyssey Tires
- michelin. Defender 2. 4.8 Read Reviews (8490) Better stopping distances and all-season grip.
- yokohama. YK-CTX. 4.7 Read Reviews (3270)
- Pro G5 CSV. 4.6 Read Reviews (4604) All-season luxury performance for your CUV.
- goodyear. Assurance MaxLife 2. Maxed-out treadlife for your vehicle.


